NALOXONE AUTO-INJECTOR is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression in adults and pediatric patients.

NALOXONE AUTO-INJECTOR is intended for immediate administration as emergency therapy in settings where opioids may be present.

NALOXONE AUTO-INJECTOR is not a substitute for emergency medical care.

How to Use Evzio Video
The NALOXONE AUTO-INJECTOR works identical to the EVZIO device in this instructional video.

See how NALOXONE AUTO-INJECTOR works

See instructions for use

How to use NALOXONE AUTO-INJECTOR

Step 1

Pull NALOXONE AUTO-INJECTOR from the outer case.

Do not go to Step 2 (Do not remove the Red safety guard) until you are ready to use NALOXONE AUTO-INJECTOR. If you are not ready to use NALOXONE AUTO-INJECTOR, put it back in the outer case for later use.

Step 2

Pull off the Red safety guard.

To reduce the chance of an accidental injection, do not touch the Black base of the auto-injector, which is where the needle comes out. If an accidental injection happens, get medical help right away.

Note: The Red safety guard is made to fit tightly. Pull firmly to remove. Do not replace the Red safety guard after it is removed.

Step 3

Place the Black end of NALOXONE AUTO-INJECTOR against the outer thigh, through clothing, if needed. Press firmly and hold in place for 5 seconds. If you give NALOXONE AUTO-INJECTOR to an infant less than 1 year old, pinch the middle of the outer thigh before you give NALOXONE AUTO-INJECTOR and continue to pinch while you give NALOXONE AUTO-INJECTOR.

Note: NALOXONE AUTO-INJECTOR makes a distinct sound (click and hiss) when it is pressed against the thigh. This is normal and means that NALOXONE AUTO-INJECTOR is working correctly. Keep NALOXONE AUTO-INJECTOR firmly pressed on the thigh for 5 seconds after you hear the click and hiss sound. The needle will inject and then retract back up into the NALOXONE AUTO-INJECTOR and is not visible after use.

Step 4

After using NALOXONE AUTO-INJECTOR, get emergency medical help right away. If symptoms return after an injection with NALOXONE AUTO-INJECTOR, an additional injection using another NALOXONE AUTO-INJECTOR may be needed. Give additional injections using a new NALOXONE AUTO-INJECTOR every 2 to 3 minutes and continue to closely watch the person until emergency help is received. NALOXONE AUTO-INJECTOR does not take the place of emergency medical care.

NALOXONE AUTO-INJECTOR cannot be reused. After use, place the auto-injector back into its outer case. Do not replace the Red safety guard.

For more detailed information on how to use NALOXONE AUTO-INJECTOR, click here.

To report an adverse event or product complaint about EVZIO or the authorized generic NALOXONE AUTO-INJECTOR, please call 1-855-625-6966.

INDICATION

What is NALOXONE AUTO-INJECTOR?

NALOXONE AUTO-INJECTOR is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

NALOXONE AUTO-INJECTOR is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of NALOXONE AUTO-INJECTOR, even if the person wakes up.

NALOXONE AUTO-INJECTOR is safe and effective in children for known or suspected opioid overdose.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NALOXONE AUTO-INJECTOR?

NALOXONE AUTO-INJECTOR is used to temporarily reverse the effects of opioid medicines. The medicine in NALOXONE AUTO-INJECTOR has no effect in people who are not taking opioid medicines. Always carry NALOXONE AUTO-INJECTOR with you in case of an opioid emergency.

Who should not use NALOXONE AUTO-INJECTOR?

Do not use NALOXONE AUTO-INJECTOR if you are allergic to naloxone hydrochloride or any of the ingredients in NALOXONE AUTO-INJECTOR.

What are the ingredients in NALOXONE AUTO-INJECTOR?

Active ingredient: naloxone hydrochloride
Inactive ingredients: sodium chloride, hydrochloric acid to adjust pH, and water

What should I tell my healthcare provider before using NALOXONE AUTO-INJECTOR?

Tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NALOXONE AUTO-INJECTOR?

NALOXONE AUTO-INJECTOR may cause serious side effects, including:

Common side effects of NALOXONE AUTO-INJECTOR include dizziness and injection site redness.

These are not all of the possible side effects of NALOXONE AUTO-INJECTOR. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click for full Prescribing Information and Patient Information.

What is NALOXONE AUTO-INJECTOR?

NALOXONE AUTO-INJECTOR is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. NALOXONE AUTO-INJECTOR is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of NALOXONE AUTO-INJECTOR, even if the person wakes up. NALOXONE AUTO-INJECTOR is safe and effective in children for known or suspected opioid overdose.

Important Safety Information

What is the most important information I should know about NALOXONE AUTO-INJECTOR?

NALOXONE AUTO-INJECTOR is used to temporarily reverse the effects of opioid medicines. The medicine in NALOXONE AUTO-INJECTOR has no effect in people who are not taking opioid medicines. Always carry NALOXONE AUTO-INJECTOR with you in case of an opioid emergency.

INDICATION

What is NALOXONE AUTO-INJECTOR?

NALOXONE AUTO-INJECTOR is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.